Doctor Doom has taken over the world, and Earth's mightiest heroes have failed twice: first to stop him, and now to overthrow him. But the Fantastic Four know Doom better than anyone, which makes them ideally suited to take on Earth's new Emperor...except for the fact that he knows THEM just as well. As Reed Richards, Ben Grimm, and Sue and Johnny Storm prepare to face down Doom at the United Nations, Doom pays a secret visit to speak to the only person on Earth who holds both his favor, his respect...and his love. But can Valeria Richards change her uncle's mind? And if she fails, what will stop Doom from visiting a shocking fate on the Fantastic Four that not even he can undo?

And, as the Avengers reel from their losses, the course of the Marvel Universe will change - and Marvel's First Family won't be the same!